We seek to understand how individual amino acids contribute to protein function in live cells, in rare disease, and during infections by ancient and emergent pathogens. Our technology-led approach allows us to do this at scale for allosteric sites, covalently druggable residues, sites of post-translational modification, and disease-associated missense variants
the lab
The Child Lab was founded in 2016 with a mission to use cutting-edge pan-disciplinary techniques to investigate novel or technically challenging scientific questions.
Our ethos is that the most interesting questions are those that have not yet been asked, that experimental controls give data meaning, and that rigorous science yields the truest result. Celebrate success, learn from failure.
Current research interests include the interpretation of reactive oxygen species by Toxoplasma, probing therapeutic targets with antimicrobial covalent inhibitors, in vivo host-pathogen studies for within-host population genetics and drug discovery, and proteome engineering for the prioritization of electrophile-sensitive amino acids.
the lab
The Child Lab was founded in 2016 with a mission to use cutting-edge pan-disciplinary techniques to investigate novel or technically challenging scientific questions.
Our ethos is that the most interesting questions are those that have not yet been asked, that experimental controls give data meaning, and that rigorous science yields the truest result. Celebrate success, learn from failure.
Current research interests include the interpretation of reactive oxygen species by Toxoplasma, probing therapeutic targets with antimicrobial covalent inhibitors, in vivo host-pathogen studies for within-host population genetics and drug discovery, and proteome engineering for the prioritization of electrophile-sensitive amino acids.
imperial college
We are based at Imperial College London's South Kensington campus, right at the heart of London, UK.
Physically located within the Sir Alexander Fleming building as part of the Department of Life Sciences, the lab has access to cutting edge technologies and the brightest minds to ensure no scientific question remains unanswered.
Imperial College's scientific reputation speaks for itself. The research strengths of the college in parasite and chemical biology complement our own research interests and helps foster a strongly collaborative environment.
imperial college
We are based at Imperial College London's South Kensington campus, right at the heart of London, UK.
Physically located within the Sir Alexander Fleming building as part of the Department of Life Sciences, the lab has access to cutting edge technologies and the brightest minds to ensure no scientific question remains unanswered.
Imperial College's scientific reputation speaks for itself. The research strengths of the college in parasite and chemical biology complement our own research interests and helps foster a strongly collaborative environment.