2022

Benns, HJ., Storch, M., Falco, JA. Fisher, FR., Tamaki, F., Alves, E., Wincott, CJ., Milne, R., Wiedemar, N., Craven, G., Baragaña, B., Wyllie, S., Baum, J., Baldwin,GS., Weerapana, E., Tate, EW., Child, MA. CRISPR-based oligo recombineering prioritizes apicomplexan cysteines for drug discovery. Nat Microbiol 7, 1891–1905 (2022). PMID: 36266336. PDF.

*highlighted with a ‘Spotlight’ article in Trends in Parasitology: Bogyo, M. Finding optimal drug target sites in parasite pathogens. Trends in Parasitology (2022).

Wincott, CJ., Sritharan, G., Benns, HJ., Liakath, FB., Carbajo, CG., Bunyan, M., Fairweather, AR., Alves, E., Andrew, I., Game, L., Frickel, EM., Tiengwe, C., Ewald, SE., Child, MA. Cellular barcoding of protozoan pathogens reveals the within-host population dynamics of Toxoplasma gondii host colonization. Cell Reports Methods 2 (2022)*. PMID: 36046624. PDF.

*highlighted with a ‘Spotlight’ article in Trends in Parasitology: Koshy, AA. Parasite potpourri: Toxoplasma gondii lineage tracing in vivo. Trends in Parasitology (2022).

Kolli, SK., Molina-Cruz, A., Araki, T., Geurten, FJA., Ramesar, K., Chevalley-Maurel, S., Kroeze, HJ., Bezemer, S.,  de Kornea, C.,  Withers, R., Raytselis, N., El Hebieshy, AF., Kim, RQ., Child, MA., Kakuta, S., Hisaeda, H., Kobayashi, H., Annoura, T., Hensbergen, PJ., Franke-Fayard, BM., Barillas-Mury, C., Scheeren, FA., Janse, CJ. Malaria parasite evades mosquito immunity by glutaminyl cyclase mediated posttranslational protein modification. Proceedings of the National Academy of Sciences 119, e2209729119, (2022). PMID: 35994647. PDF.

Jeffers, V. & Child, MA. No acetyl-CoA keeps Plasmodium at bay. Cell Chem Biol 29, 174-176 (2022). PMID: 35180431. PDF.

2021

Alves, E., Benns, HJ., Magnus, L., Dominicus, C., Dobai, T., Blight, J., Wincott, CJ., Child, MA. An Extracellular Redox Signal Triggers Calcium Release and Impacts the Asexual Development of Toxoplasma gondii. Front. Cell. Infect. Microbiol., 2021 Aug 10;11:728425. PMID: 34447699. PDF.

2020

Benns, HJ.*, Wincott, CJ.*, Tate, EW., Child, MA. Activity- and reactivity-based proteomics: Recent technological advances and applications in drug discovery. Curr Opin Chem Biol 2020 Aug 5;60:20-29. PMID: 32768892. PDF. * indicates shared first authorship.

Anderson, DP., Benns, HJ., Tate, EW., Child, MA. CRISPR-TAPE: protein-centric CRISPR guide design for targeted proteome engineering. Mol Syst Biol (2020) 16:e9475. PMID: 32485092. PDF.

2018

Benns, HJ., Tate, EW., Child, MA. Activity-Based Protein Profiling for the Study of Parasite Biology. Curr Top Microbiol Immunol. 2018 Aug 14. PMID: 30105424. PDF.

Garland, M., Schulze, CJ., Foe, IT., van der Linden, WA., Child, MA.*, Bogyo, M.* Development of an activity-based probe for acyl-protein thioesterases. PLoS ONE 2018, 13(1): e0190255.  PMID: 29364904. PDF. * indicates co-corresponding authorship.

2017

Child, MA., Garland, M., Foe, I., Madzelan, P., Treeck, M., van der Linden, WA., Oresic Bender, K., Weerapana, E., Wilson, MA., Boothroyd, JC., Reese, ML., Bogyo, M. Toxoplasma DJ-1 Regulates Organelle Secretion by a Direct Interaction with Calcium-Dependent Protein Kinase 1. MBio. 2017 Feb 28;8(1). pii: e02189-16. PMID: 28246362. PDF

2015

Foe, I.*, Child, MA.*, Majudar, J.*, Krishnamurthy, S., Ward, GE., Martin, B., Bogyo, M. Global Analysis of Palmitoylated Proteins in Toxoplasma gondii. Cell Host & Microbe 10/2015; 18(4):501-511. PMID: 26468752. PDF. * indicates shared first authorship.

Bender, KO., Garland, M., Ferreyra, JA., Hryckowian, AJ., Child, MA., Puri, AW., Solow-Cordero, DE., Higginbottom, SK., Segal, E., Banaei, N., Shen, A., Sonnenburg, JL., Bogyo, M. A small-molecule antivirulence agent for treating Clostridium difficile infection. Sci Transl Med. 2015 Sep 23;7(306):306ra148. PMID: 26400909. PDF

van der Linden, WA., Segal, E., Byzia, A., Child, MA., Drąg, M., Bogyo, M. Design and synthesis of activity-based probes and inhibitors for bleomycin hydrolase. Chem Biol. 2015 Aug 3. PMID: 26256478. PDF

2014

Treeck, M., Sanders, JL., Gaji, RY., LaFavers, KA., Child, MA., Arrizabalaga, G., Elias, JE., Boothroyd, JC. The Calcium-Dependent Protein Kinase 3 of Toxoplasma Influences Basal Calcium Levels and Functions beyond Egress as Revealed by Quantitative Phosphoproteome Analysis. PLoS Pathog. 2014 Jun 19;10(6). PMID: 24945436. PDF

2013

Child, MA. Chemical Biology Approaches for the study of Apicomplexan Parasites. Mol Biochem Parasitol (2013);192(1-2):1-9. PMID: 24333788. PDF

Child, MA., Hall, CI., Beck, JR., Ofori, LO., Albrow, VE., Garland, M., Bowyer, PW., Bradley, PJ., Powers, JC, Boothroyd, JC., Weerapana, E., Bogyo, M. Small-molecule inhibition of a depalmitoylase enhances Toxoplasma host-cell invasion. Nat Chem Bio (2013) 9(10):651-6. PMID: 23934245. PDF

Child, MA., Harris, PK., Collins, CR., Withers-Martinez, C., Yeoh, S., Blackman, MJ. Molecular determinants for subcellular trafficking of the malarial sheddase PfSUB2. Traffic (2013) 14(10):1053-64. PMID: 23834729. PDF

2012

Li, H., Child, MA., Bogyo, M. Proteases as regulators of pathogenesis: Examples from the apicomplexa. Biochim Biophys Acta (2012) 1824(1):177-85. PMID: 21683169. PDF

2011

Hall, CI., Reese, ML., Weerapana, E., Child, MA., Bowyer, PW., Albrow, VE., Haraldsen, JD., Phillips, MR., Sandoval, ED., Ward, GE., Cravatt, BF., Boothroyd, JC., Bogyo, M. Chemical genetic screen identifies Toxoplasma DJ-1 as a regulator of parasite secretion, attachment, and invasion. PNAS (2011) 108(26):10568-73. PMID: 21670272. PDF

2010

Child, MA., Epp, C., Bujard, H., Blackman, MJ. Regulated maturation of malaria merozoite surface protein-1 is essential for parasite growth. Mol Micro (2010) 78(1):187-202. PMID: 20735778. PDF

2009

Koussis, K., Withers-Martinez, C., Yeoh, S., Child, M., Hackett, F., Knuepfer, E., Juliano, L., Woehlbier, U., Bujard, H., Blackman, MJ. A multifunctional serine protease primes the malaria parasite for red blood cell invasion. The EMBO Journal (2009) 28(6):725-35. PMID: 19214190. PDF