An aspect of the host redox machinery yet to be studied in the context of intracellular pathogens is the recently discovered redox circadian rhythm (RCR). Though our understanding of the molecular basis for this oscillation remains incomplete, it is present in all domains of life and is independent of canonical transcription-factor clock machinery. Distinguishing the contribution of the redox rhythm from clock transcription factors to biological processes is challenging, but enucleated mature erythrocytes provide an ideal system for its study, where the RCR is present but canonical circadian clock components and structures are notably absent. Intracellular pathogens that infect erythrocytes (such as Plasmodium spp.) provide a unique opportunity to study the host-cell RCR within the context of a pathogenic infection and is a second major research interest of our lab.